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Psych Scene with Dr. Sanil Rege --- How Psychiatric Disorders Overlap with Autoimmune Disorders

1/30/2026

Val's Take/Conjecture

So one of the things that has happened is the recognition of a Neuro-Developmental --- Psychiatric Continuum --- those DISTINCT DIAGNOSES in the DSM often don't match neatly to "REALITY."

One of the biggest SEEMING CONTRADICTIONS is that we recognize Neuro-Developmental Disorders much more in MEN and Psychiatric Disorders --- much more in women. Hmmm . . .

There are sex differences.

The next step has been recognizing there is a lot of overlap between other illnesses and diseases and Neuro-Developmental and Psychiatric Disorders.

Stanford Medicine-led study shows why women are at greater risk of autoimmune disease (2024)

"Research throws light on the mystery of why women are much more prone to autoimmune disorders: A molecule made by one X chromosome in every female cell can generate antibodies to a woman's own tissues."

Cancer & Neuro-Diversity: The Crying Need for an Integrated Physical & Mental Health Care System

Neuro-Diversity and Its relation not only to Psychiatric Disorders but also Metabolic Disorders, Cancer & Autoimmune Diseases

The Academy by Psych Scene
Dr. Sanil Rege

How Psychiatric Disorders Overlap with Autoimmune Disorders (2026)

Why are brain tumors more common in men? (2014)

"The reason why brain tumors occur more frequently in males and are often more harmful than single tumors in females has been further explained by new research from Washington University School of Medicine in St Louis (MO, USA).

"Glioblastomas, which are the most common malignant brain tumors, for example, are diagnosed twice as often in males and result in greater cognitive impairments than when occurring in females; male patients also do not survive as long.

"A protein known to reduce cancer risk termed retinoblastoma protein (RB) was demonstrated by the researchers to be significantly less active in male brain cells than in female brain cells."

Astrocytes from People with schizophrenia induce "DYSTROPHIC" Microglia-like Cells

1/5/2026

hiPSC-Derived Astrocytes From Individuals With Schizophrenia

Induce a Dystrophic Phenotype in Microglial-Like Cells (2026)

University of Kentucky's Institutional Repository
Theses & Dissertations -- Neuroscience

The Role of Dystrophic Microglia in Aging and Disease (2024)

Traditionally, microglial subtypes characterized physiologically as “reactive” or “activated” have been linked with disease and injury in the brain.

However, morphologically, a recently described microglia category known as “dystrophic,” characterized structurally by fragmented processes and cytoplasmic decay is believed to be more strongly associated with aging and neurodegeneration.

Affiliations
1Department of Biochemistry and Immunology, Institute of Biological Sciences (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
2Department of Genetics, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
3D'or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
4Molecular Carcinogenesis Program, Research Coordination, Instituto Nacional do Câncer (INCA), Rio de Janeiro, Brazil.
5Vice-Presidency of Research and Biological Collections (VPPCB), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
6Department of Pharmacology, Institute of Biological Sciences (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
7Department of Psychiatry, Faculty of Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
8Department of Psychiatry, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
9Department of Genetics, Institute of Biology, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

Translational Medicine Friday

We're riffing off NPR's Science Friday to create Translational Medicine Friday.

We'll be collecting Research Article recommendations for Clinicians with regard to Cognitive Disability.

There is much in the RESEARCH JOURNALS and we'll just be SKIMMING THE SURFACE.

The POINT is to INCREASE FUNDING for TRANSLATIONAL RESEARCH at the Federal Level for the National Institutes of Health, the Centers for Disease Control, the Nation's Research & Teaching Hospitals and possible collaborations with Medicare and Medicaid providers.

Translational Medicine Friday

Psych Scene with Dr. Sanil Rege --- How Psychiatric Disorders Overlap with Autoimmune Disorders

Astrocytes from People with schizophrenia induce "DYSTROPHIC" Microglia-like Cells

Translational Medicine Friday

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