Orchid A-Z Index

WHAT'S THE POINT?

Understanding the Immune System as a Key Component of Neuro-Developmental & Psychiatric Disorders is a MAJOR PARADIGM SHIFT.

Is it the final word --- probably not. But we need to shed our antiquated understandings so we can get to something BETTER.

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders (2015)

*Wales and Australia

Immune Dysregulation in Bipolar Disorder:
The Role of IL-27 and EBI3 (2025)

*Researchers from Iran & the UK

The China Brain Multi-omics Atlas Project (CBMAP) (2026)

Prospective association between maternal allostatic load during pregnancy and child mitochondrial content and bioenergetic capacity (2022)

Mitochondria: A Unifying Link for Psychiatric Illness
Psychological stress gets embedded in our system by altering metabolism. (2024)

A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder (2025)

*US

Mitochondrial dynamics and psychiatric disorders: The missing link (2024)

*Greece

Microglia as hunters or gatherers of brain synapses (2025)

Role of the T-cell network in psychiatric disorders (2021)

Crisis Services in Colorado, the US & Around the World

Val's Take/Conjecture

So first, the information from the US National Institute of Health and others on Fibromyalgia, Chronic Fatigue Syndrome and various links with ADHD and Autism is important.
The Pharrell Williams video is to CELEBRATE this knowledge with the anticipation of more --- while recognizing the great DIVERSITY out there and the need for PRECISION MEDICINE.
Without a concept like the EXPOSOME --- I think it is hard to wrap one's head around the great diversity that's out there.

So people who are Neuro-Diverse are BURNING OUT and BREAKING DOWN MORE.
So I do think it is important to recognize that your brain is giving you signals that you are tired, and maybe your muscles aren't tired.
BUT -- what is a potential risk of ignoring those signals --- I would say MALADAPTIVE SYNAPSE TRIAGING --- which could lead to more serious psychiatric disorders, and in a worst case scenario catastrophic consequences.
So on the one hand if we listen to those signals that we are tired we maybe perceived as LAZY. On the other hand, if we don't take care to operate within AVAILABLE ENERGY LIMITS or WHAT OUR BRAINS PERCEIVE TO BE AVAILABLE ENERGY LIMITS --- we may get blind-sided in ways neither we nor the Medical Establishment ever saw coming..

Also, Fibromyalgia and Chronic Fatigue Syndrome stereotypically affect women more., and maybe neuro-divergent women more.

On the other hand, men may not be as subject to Fibromyalgia or Chronic Fatigue Syndrome, BUT they are more subject to ALEXITHYMIA and INTROCEPTION Problems in which they are LESS ABLE to understand that they are fatigued.