WHAT'S THE POINT?
Understanding the Immune System as a Key Component of Neuro-Developmental & Psychiatric Disorders is a MAJOR PARADIGM SHIFT.
Is it the final word --- probably not. But we need to shed our antiquated understandings so we can get to something BETTER.
Understanding the Immune System as a Key Component of Neuro-Developmental & Psychiatric Disorders is a MAJOR PARADIGM SHIFT.
Is it the final word --- probably not. But we need to shed our antiquated understandings so we can get to something BETTER.
The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders (2015)
*Wales and Australia 
Immune Dysregulation in Bipolar Disorder:
The Role of IL-27 and EBI3 (2025) *Researchers from Iran & the UK 
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Val;s Take/Conjecture: Even before Kuhn, there were Historians in the 1950s and probably before who would say the key to NEW IDEAS gaining ascendancy is the OLD GUARD dies out.
In a medical context, the problem is often that you and the people you are concerned about are DYING OUT at a faster pace than the "OLD GUARD."
BUT as Ma Joad said in "The Grapes of Wrath": "THOSE PEOPLE KEEP COMING."
AI is imperfect and concerning and amazing all at the same time. I'm not going to review 117 million papers this afternoon for one report or multiply that several times for several reports.
Most of AI with regard to medical matters is fairly measured --- but still not perfect. We can't check our CRITICAL THINKING at the door.
When it comes to Neuro-Developmental and Psychiatric Disorders, there is a overwhelming evidence of NEURO-IMMUNE MECHANISMS and the benefit of more thoroughly integrating NEUROLOGY and PSYCHIATRY.
In a medical context, the problem is often that you and the people you are concerned about are DYING OUT at a faster pace than the "OLD GUARD."
BUT as Ma Joad said in "The Grapes of Wrath": "THOSE PEOPLE KEEP COMING."
AI is imperfect and concerning and amazing all at the same time. I'm not going to review 117 million papers this afternoon for one report or multiply that several times for several reports.
Most of AI with regard to medical matters is fairly measured --- but still not perfect. We can't check our CRITICAL THINKING at the door.
When it comes to Neuro-Developmental and Psychiatric Disorders, there is a overwhelming evidence of NEURO-IMMUNE MECHANISMS and the benefit of more thoroughly integrating NEUROLOGY and PSYCHIATRY.
Val's Take/Conjecture: This is the 2nd video I've posted from the Institute for Systems Biology.
One of the things that has happened with respect to Neuro-Developmental and Psychiatric Disorders is that we're understanding them beyond the BRAIN and the CENTRAL NERVOUS SYSTEM.
It's not that the BRAIN and CENTRAL NERVOUS SYSTEM aren't involved but they may be involved in ways we didn't appreciate ---AND it's that many other systems of the body are involved as well, including:
For a lot of complex Chronic Conditions such as Neuro-Developmental and Psychiatric Disorders, Auto-Immune Disorders, Cancer, etc. ---- A SYSTEMS BIOLOGY APPROACH IS NEEDED TO UNRAVEL THEIR COMPLEXITY.
One of the things that has happened with respect to Neuro-Developmental and Psychiatric Disorders is that we're understanding them beyond the BRAIN and the CENTRAL NERVOUS SYSTEM.
It's not that the BRAIN and CENTRAL NERVOUS SYSTEM aren't involved but they may be involved in ways we didn't appreciate ---AND it's that many other systems of the body are involved as well, including:
- The Immune System
- The Microbiome
- The Endocrine System
- The Metabolism
- And for some of us other systems such as the SKELETAL SYSTEM and BONE DISORDERS, or more of the NERVOUS SYSTEM such as the EYES, or HYPER-MOBILITY and the AUTONOMIC NERVOUS SYSTEM.
For a lot of complex Chronic Conditions such as Neuro-Developmental and Psychiatric Disorders, Auto-Immune Disorders, Cancer, etc. ---- A SYSTEMS BIOLOGY APPROACH IS NEEDED TO UNRAVEL THEIR COMPLEXITY.
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