Neuro-Immunology as it relates to Pain and emotional disorders

​Val's Take/Conjecture

• The researchers acknowledge the role of "neurotransmitters" --- but their focus is on understanding NEURO-IMMUNE MECHANISMS in Chronic Pain and Mood Disorders.
• "Psychoneuroimmunology" began in the mid-1970s.
  • ​Earlier this was very much MIND OVER MATTER.

• Interestingly in 2025 ---
  • ​It's MATTER OVER MIND
  • It's understanding complicated underlying biology that involves MULTIPLE SYSTEMS OF THE BODY.

​Neuroscientist & Author Antonio Damasio
Why the Mind Encompasses More Than Just the Brain (2016)

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​Chronic Pain and Comorbid Emotional Disorders: Neural Circuitry and Neuroimmunity Pathways (2025)

*Chinese Researchers

​Given the contribution of neuroimmune mechanisms to pain chronicity and mood disorders, we further conducted an in-depth investigation into the role of neuroimmune factors, including resident immune cells, infiltrating immune cells, and the release of inflammatory mediators.

This review further discusses current therapeutic strategies, encompassing pharmacological interventions, neuromodulation, and integrative approaches, and emphasizes the necessity of targeted treatments that address both pain and emotional components.

​Finally, it identifies gaps in the current understanding and outlines future research directions aimed at elucidating the complex interplay between chronic pain and emotional disorders, thereby laying the foundation for more effective and holistic treatment paradigms.