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Jama Psychiatry is driving another stake into DSM DIAGNOSTIC CATEGORIESwith some practical alternatives --- BIO-MARKERS

4/21/2026

Val's Take/Conjecture

Lead author of the Study to the right is Sameer Jauhar, PhD with Imperial College London.
There were also several other authors of the Study from the UK including others from Imperial College London, Oxford and King's College London, and also Italy -- the University of Padua.

DSM Categories have been under fire from the highest tops of the Scientific Establishment for over a decade.

Slowly biomarkers are being identified.

In the meantime, there are plenty of questions about how we should be handling imperfect and incomplete psychiatric knowledge in the Criminal Justice System.

There are BIG JUSTICE ISSUES here and national institutional leaders such as the Council on State Governments Justice Center and Vera Institute of Justice --- should be weighing in.

Treatment For Psychosis May Be 'Fundamentally Flawed',
Study Finds
Science Alert
August 31, 2025

"This discovery challenges some aspects of modern psychiatric practice. Currently, treatment decisions rely heavily on diagnostic categories that may not reflect what is actually happening in people's brains."

. . .

"As our understanding of the brain advances, the rigid categories that have dominated psychiatry for decades are beginning to blur. If the brain (and mother nature) does not respect diagnostic boundaries, neither should our treatments."

Dopamine and Mood in Psychotic Disorders: An 18F-DOPA PET Study (2025)

Use of PET Scan to determine Striatal dopamine synthesis capacity (Kicer).

Metabolomic Biomarker Signatures for Bipolar and Unipolar Depression (2024)

"Time is on my side," "Angel from Montgomery" --- and Justice

4/19/2026

Val's Take: "Time Is On My Side" --- will the new understandings of Neuro-Developmental and Psychiatric Disorders ultimately make their way to mainstream Healthcare --- I really have no doubt of it.

On the other hand, people living in the last 50 or 60 years have been subject to a MIXED BAG of Psychiatric Ideas and Treatments --- some of which could be LIFE SAVING, some HARMFUL and some MEH.

One of the lines in "Angel from Montgomery" is "I am an old woman --- my old man is another child who's grown old." People with Neuro-Developmental and Psychiatric Disorders die everyday without the benefit of these new understandings.

Further, there are people in Colorado prisons and homeless whose challenges are greatly misunderstood by not appreciating that they involve "immune alterations."

There was such a rejection of the "MEDICAL MODEL" --- mainly because the medical model we had was deeply flawed. "Multi-omics" is about as medical model as one can get in 2026 --- it does seem to be a BIG STEP UP --- and it should still be questioned.

We've been slow to appreciate the implications of the Research of the last 10 to 15 years --- "Just give me one thing
That I can hold on to, To believe in this livin' Is just a hard way to go."

The Rolling Stones and Irma Thomas
Time Is On My Side

Bonnie Raitt and John Prine
Angel From Montgomery

Multi-omics, Paradigm shifts and the need for sophisticated policy making

4/17/2026

Val's Take/Conjecture

Researchers around the World, including Germany, Iran, the US, China, Japan Brazil and many other countries have made a major paradigm shift when if comes to the biological understanding of Neuro-Developmental and Psychiatric Disorders.

Policymaking without PERFECT KNOWLEDGE ---
We NEVER have PERFECT KNOWLEDGE.

We need an entity like the Council on State Governments to tackle the policy challenges of MAJOR PARADIGM SHIFTS at the Research Level and Lagging Translational Research --- especially with respect to "Anti-Social Personality Disorder."

Multi-omics approaches to major psychiatric disorders (2026)

Affiliations

1Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, 80336, Munich, Germany.
2Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany.
4Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, 80336, Munich, Germany.
5Department of Psychiatry and Behavioral Sciences, Norton College of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
6Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Transitional/ Translational Justice Monday

Jama Psychiatry is driving another stake into DSM DIAGNOSTIC CATEGORIESwith some practical alternatives --- BIO-MARKERS

"Time is on my side," "Angel from Montgomery" --- and Justice

Multi-omics, Paradigm shifts and the need for sophisticated policy making

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