Nature neuroscience: the link between schizophrenia and microglia

Microglia

Cytoskeletal control in adult microglia is essential to restore neurodevelopmental synaptic and cognitive deficits (2025)

*John Hopkins University, Belgium, The Netherlands, Canada
These findings reveal a pivotal role for microglial actin cytoskeletal remodeling in preserving synaptic integrity and cognitive health.

​Targeting microglial cytoskeletal dynamics may effectively address cognitive impairments associated with NDDs [Neuro-Developmental Disorders], even in adulthood.


Microglia

in Neuro-Developmental & Psychiatric Disorders

A Neuro-Immune Paradigm Shift


The Endocrine System and Microglia

1.  History: 
  • The Historical Development of Immunoendocrine Concepts of Psychiatric Disorders and their Therapy
  • 2015 Study

2.  Maternal Immune Activation
  • Influence of innate immune activation on endocrine and metabolic pathways in infancy
    • 2021 Study
  • Immune-Endocrine Cross Talk
  • Activation of the maternal immune system induces changes in the placenta via IL-6
    • 2011 Study

3.  Misc.
  • Can Ashwagandha Benefit the Endocrine System
    • 2023 Study
  • Medical comorbidity in bipolar disorder:  relatioship between illnesses of the endocrine/metabolic meystem and treatment outcome.
    • 2010 Study
  • Neuroendorine Stress System in Bipolar
    • 2021 Study
  • Corticotropin-releasing hormone, microglia and mental disorders
    • 2014 Study
  • Microglia:  Neuroimmune-Sensors of Stress
    • 2019 Study
​4.  Endocrine Disruptors
  • The research lanscape concerning environmental factors in neurodevelopmental disorders
    • ​2024 Study
  • Editorial:  Endocrine disruptors and diseases of brain and mind:  past and prelude
    • 2024 Frontiers in Endocrinology
  • Linking Environmental and Autism Spectrum Disorder:  Mechanisms and Implications for Prevention
    • ​​2024 Study