Genomic complexities in inborn errors of immunity
Are your diagnostic approaches keeping pace with the evolving genetic landscape? (2026)

Inborn errors of immunity:

an expanding universe of disease and genetic architecture (2024)

Center for Inborn Errors of Immunity, Precision Immunology Institute, Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai
Inborn errors of immunity (IEIs) are generally considered to be rare monogenic disorders of the immune system that cause immunodeficiency, autoinflammation, autoimmunity, allergy and/or cancer.

Here, we discuss evidence that IEIs need not be rare disorders or exclusively affect the immune system.

Namely, an increasing number of patients with IEIs present with severe dysregulations of the central nervous, digestive, renal or pulmonary systems.

In-Born errors of Immunity link to Neurodevelopmental and psychiatric Disorders

through Shared Genetic, neuroinflammation aNd Maternal immune activation