Modern Medicine Network
Mood Disorders and Rheumatoid Arthritis
http://www.rheumatologynetwork.com/rheumatoid-arthritis/mood-disorders-and-rheumatoid-arthritis-updates-eular-2018


Arthritis & the Immune System & Mental Health

Consensus AI Reports were added May 3, 2026
"There is a strong, bidirectional association between arthritis (especially autoimmune/inflammatory types) and neurodevelopmental and psychiatric disorders—particularly depression, anxiety, ADHD, and cognitive impairment—driven by shared genetic risk, chronic inflammation, immune dysregulation, pain, and psychosocial stress."
"Yes, immune dysregulation—characterized by aberrant activation of both innate and adaptive immune responses, loss of tolerance, and chronic inflammation—is central to the development, progression, and severity of both rheumatoid arthritis (RA) and osteoarthritis (OA)."